Fish fend off invading germs with an initial response

September 25, 2009 at 12:58 pm Leave a comment

Since the human response to infection is highly complex, research to understand how people fight infection is facilitated by studying how similar processes occur in simpler organisms. Zebrafish are becoming an important model for human disease, since they are easily handled, maintained and manipulated and a number of fundamental processes between zebrafish and humans are conserved. In addition, the small zebrafish embryo is highly amenable to drug screening assays. The functional similarity between the initial responses of zebrafish embryo and humans to infection suggests that the zebrafish embryo appears to be a valuable model for understanding early immune responses and identifying potential therapeutics for infection or immune mediated disease. However, the initial response of zebrafish to infection and how it compares to the human response is not well understood……..
http://www.biology-blog.com/blogs/permalin…

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